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Pamoic acid is a dicarboxylic acid derived from naphthoic acid. In pharmacology, the salt form of pamoic acid (pamoate ion) can be used as a drug compound counterion to affect the dissolution rate of the drug.
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A potent agonist of GPR35 orphan receptors (EC50 = 79 nM in a β-arrestin recruitment assay); induces GPR35 translocation from the plasma membrane to the cytoplasm (EC50 =22 nM); increases ERK1/2 phosphorylation in a concentration-dependent manner in U20S cells expressing human GPR35a; has antinociceptive effects in a mouse abdominal constriction model of visceral pain perception (ED50 = 40.5 mg/kg)
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